For US Residents
Get access to the support you need in just 2-3 minutes.
See all thatNovartis Patient Supportcan offer:
Financial Support
Provide you with financial support options. You could pay as little as $0 with the Co-Pay Plus* offer.
Insurance Support
Answer questions about your insurance coverage. We'll help you navigate the process.
Ongoing Support
Get useful tips, resources, and reminders throughtout your treatment.
If you’d like to sign up on the phone, call 844-4VANRAF (844-482-6723), Monday-Friday, 8:00 AM-8:00 PM ET (excluding holidays).
*
Co-Pay Plus: Limitations apply. Valid only for those with private insurance. The Program includes the Co-Pay Plus offer, Plus Card (if applicable), and Rebate, with a combined annual limit up to $15,000. Patient is responsible for any costs once limit is reached in a calendar year. Program not valid (i) under Medicare, Medicaid, TRICARE, VA, DoD, or any other federal or state health care program, (ii) where patient is not using insurance coverage at all, (iii) where the patient’s insurance plan reimburses for the entire cost of the drug, or (iv) where product is not covered by patient’s insurance. The value of this program is exclusively for the benefit of patients and is intended to be credited towards patient out-of-pocket obligations and maximums, including applicable co-payments, coinsurance, and deductibles. Program is not valid where prohibited by law. Patient may not seek reimbursement for the value received from this program from other parties, including any health insurance program or plan, flexible spending account, or health care savings account. Patient is responsible for complying with any applicable limitations and requirements of their health plan related to the use of the Program. Valid only in the United States and Puerto Rico. This Program is not health insurance. Program may not be combined with any third-party rebate, coupon, or offer. Proof of purchase may be required. Novartis reserves the right to rescind, revoke, or amend the Program and discontinue support at any time without notice.

Bridge Program: The Bridge Program applies to VANRAFIA only. Eligible patients must have private insurance and a valid prescription for VANRAFIA, and a prior authorization or an initial denial of coverage. Program requires the submission of an appeal of the coverage denial within the first 90 days of enrollment to remain eligible. Program provides VANRAFIA for free to eligible patients for up to 12 months, or until they receive insurance coverage approval, whichever occurs earlier. A valid prescription consistent with FDA-approved labeling is required. Program is not available to patients whose medications are reimbursed in whole or in part by Medicare, Medicaid, TRICARE, or any other federal or state program. Patients may be asked to reverify insurance coverage status during the course of the program. No purchase necessary. Program is not health insurance, nor is participation a guarantee of insurance coverage. Additional Limitations may apply. Novartis Pharmaceuticals Corporation reserves the right to rescind, revoke, or amend this Program without notice.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about VANRAFIA?

VANRAFIA can cause serious birth defects if taken during pregnancy. Females should not be pregnant when they start taking VANRAFIA, become pregnant during treatment, or for 2 weeks after stopping treatment. Females who can become pregnant should have a negative pregnancy test before starting VANRAFIA.

Females who can become pregnant are those who:

  • Have entered puberty, even if they have not started their menstrual period, and
  • Have a uterus, and
  • Have not gone through menopause. Menopause means that you have not had a menstrual period for at least 12 months for natural reasons, or that you have had your ovaries removed.

Females who cannot become pregnant are those who:

  • Have not yet entered puberty, or
  • Do not have a uterus, or
  • Have gone through menopause. Menopause means that you have not had a menstrual period for at least 12 months for natural reasons, or that you have had your ovaries removed, or
  • Are infertile for any other medical reason and this infertility is permanent and cannot be reversed.

Females who can become pregnant should use effective birth control before starting treatment with VANRAFIA, during treatment with VANRAFIA, and for 2 weeks after stopping VANRAFIA because the medicine may still be in your body.

Talk to your health care provider or gynecologist (a health care provider who specializes in reproduction) to find out about options for effective forms of birth control that you may use to prevent pregnancy during treatment with VANRAFIA.

If you decide that you want to change the form of birth control that you use, talk to your health care provider or gynecologist to be sure that you choose another effective form of birth control.

Do not have unprotected sex. Talk to your health care provider or pharmacist right away if you have unprotected sex or if you think your birth control has failed. Your health care provider may talk to you about using emergency birth control.

Tell your health care provider right away if you miss a menstrual period or think you may be pregnant.

Who should not take VANRAFIA?

Do not take VANRAFIA if you are:

  • Pregnant, plan to become pregnant, or become pregnant during treatment with VANRAFIA. VANRAFIA can cause serious birth defects.
  • Allergic to atrasentan or any of the ingredients in VANRAFIA.

Before taking VANRAFIA, tell your health care provider about all your medical conditions, including if you:

  • Have liver problems.
  • Are pregnant or plan to become pregnant during VANRAFIA treatment. VANRAFIA can cause serious birth defects.
  • Are breastfeeding or plan to breastfeed. It is not known if VANRAFIA passes into your breast milk. Do not breastfeed during treatment with VANRAFIA. Talk to your health care provider about the best way to feed your baby if you take VANRAFIA.

Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking VANRAFIA with certain medications may affect the way VANRAFIA, and the other medicine works and may increase your risk for side effects. Do not start any new medicine until you check with your health care provider.

What are the possible side effects of VANRAFIA?

VANRAFIA may cause serious side effects, including:

  • Serious birth defects.
  • Liver problems. Medicines like VANRAFIA can cause liver problems, including liver failure. VANRAFIA can increase liver enzymes in your blood. Your health care provider will do blood tests to check your liver enzymes before starting treatment and if needed during treatment. Your health care provider may temporarily stop or permanently stop treatment with VANRAFIA if your liver enzymes increase or if you develop symptoms of liver problems. Tell your health care provider if you have any of the following symptoms of liver problems while taking VANRAFIA:
    • Nausea or vomiting
    • Pain in the upper right stomach
    • Tiredness
    • Loss of appetite
    • Yellowing of your skin or whites of your eyes
    • Dark urine
    • Fever
    • Itching
  • Fluid retention. VANRAFIA can cause your body to hold too much water. Tell your health care provider if you develop any unusual weight gain, trouble breathing, or swelling of your ankles or legs during treatment. Your health care provider may prescribe other medicines (diuretics) and may temporarily stop VANRAFIA if you develop fluid retention.
  • Decreased sperm count. VANRAFIA may cause decreased sperm counts in males and may affect the ability to father a child. Tell your health care provider if being able to have children is important to you.

The most common side effects of VANRAFIA include:

  • Swelling of the hands, legs, ankles, and feet (peripheral edema)
  • Low red blood cell count (anemia)

These are not all of the possible side effects of VANRAFIA. Call your health care provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

APPROVED USE

What is VANRAFIA?

VANRAFIA is a prescription medicine used to reduce protein in the urine (proteinuria) in adults with a kidney disease called primary immunoglobulin A nephropathy (IgAN) who are at risk of their disease getting worse quickly. It is not known if VANRAFIA is safe and effective in children.

VANRAFIA is approved based on a reduction of proteinuria. Continued approval may require results from an ongoing study to determine whether VANRAFIA slows decline in kidney function.